- Title
- Noncoding RNA regulation of dopamine signaling in diseases of the central nervous system
- Creator
- Carrick, William T.; Burks, Brandi; Cairns, Murray J.; Kocerha, Jannet
- Relation
- Frontiers in Molecular Biosciences Vol. 3
- Publisher Link
- http://dx.doi.org/10.3389/fmolb.2016.00069
- Publisher
- Frontiers Research Foundation
- Resource Type
- journal article
- Date
- 2016
- Description
- Dopaminergic neurotransmission mediates a majority of the vital central nervous system functions. Disruption of these synaptic events provokes a multitude of neurological pathologies, including Parkinson's, schizophrenia, depression, and addiction. Growing evidence supports a key role for noncoding RNA (ncRNA) regulation in the synapse. This review will discuss the role of both short and long ncRNAs in dopamine signaling, including bioinformatic examination of the pathways they target. Specifically, we focus on the contribution of ncRNAs to dopaminergic dysfunction in neurodegenerative as well as psychiatric disease.
- Subject
- microRNAs; psychiatric; neurodegeneration; noncoding RNA; dopaminergic; schizophrenia; dopamine; epigenetic
- Identifier
- http://hdl.handle.net/1959.13/1325726
- Identifier
- uon:25334
- Identifier
- ISSN:2296-889X
- Rights
- © 2016 Carrick, Burks, Cairns and Kocerha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
- Language
- eng
- Full Text
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